Something sinister happened to Mackenzie's twin sister Breanne the last time the two girls were in Ireland. Now they're back and the winter solstice is approaching. Breanne scoffs at their elderly relatives' tales of fair folk and banshees and the thin barrier between two worlds, but Mackenzie remembers what happened to Breanne five years before, at the summer solstice. Mackenzie is convinced the Otherworld is real, but is it a place of enchantment or enslavement for humans?
Chloe McBride has some reservations about accepting her elderly great-aunts' invitation to spend part of the summer with them in Little Venice, but her initial reluctance is outweighed by her curiosity about the mysterious key that came with her aunts' note. She's also anxious to put the humiliating memory of a disastrous piano recital as far behind her as possible. Chloe's great-aunts tell her the legend of her great-grandfather, Dante Magnus, an ambitious magician who vanished without a trace almost a century earlier, and Chloe begins to search for clues to his disappearance. When her investigations eventually lead her to a mysterious rosewood box, which has been hidden for almost a hundred years, Chloe's belief in the power of magic forces her to confront her own fears and ambitions.
Byron is psyched when his older brother Jesse invites him on a weekend caving trip—even if it means spending time with Cole, Jesse's obnoxious college roommate. With Jesse's girlfriend Michelle rounding out the group, Byron is sure the excursion will be a success. Things get tense when they near the cave, only to find that the way in is blocked. Byron stumbles on the entrance to a new cave, but the thrill of his discovery is overshadowed by Cole's increasingly strange behavior. Exploring a wild cave is always dangerous, but it becomes deadly as tempers fray and the water level inside the cave starts to rise. When an underground confrontation leaves his brother seriously injured, Byron has to make some life-or-death decisions—and every second counts.
Sam Stringbini, the youngest son in a family of circus performers, is living every kid's dream, except for the fact that he is no good on the high wire, trapezes freak him out and magic mystifies him. When the Triple Top Circus is threatened by repeated acts of sabotage, Sam is the number one suspect. To clear his name, Sam enlists the help of his cousin, Harriet, and discovers that, while he may never be a sword-swallower or a lion-tamer, he just might be able to save the circus.
Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.